Study of EBV and Associated Gastric Malignancies

Introduction: Epstein Barr virus (EBV), is a member of the genus Lymphocryptoviridae and Herpesviridae subfamily. It pervasive infects more than 90% adult population worldwide. In childhood early adulthood primary infection occurs through salivary contact. The majority children are asymptomatic, but some adolescents young adults can develop infectious mononucleosis with harmless clinical manifestations.
 Objective: To analyze expression Virus (EBV) Latent membrane protein – 1 (LMP-1) in various histological subtypes gastric carcinoma.
 Materials Methods: Out 43cases, 32 cases were proven to be malignant, out which 30 who had adequate data included study. materials processed sections cut at 5 microns. Hematoxylin eosin staining was done. Histopathological examination these done.
 Result: most common presenting symptom associated Gastric carcinoma upper abdominal pain (epigastric pain). Both LMP-1 IHC positive showed low score when assessed using immunohistochemistry scoring system (used nasopharyngeal carcinomas). This may due older age group patients. For effective control viral cancer, there should rapid, sensitive, specific, cost-effective diagnostics assays management.
 Conclusion: Hence our study justifies role EBV oncogenesis carcinoma. More elaborate extensive studies warranted further emphasize this theory.